Despite the title of this post, I actually like Brussels as a city, and have fond memories of visiting friends who used to live there (Hi Ralph & Sheena).
In the late 21st Century of the ‘Stars’ trilogy, I’ve used the city for a more sinister purpose. Brussels becomes the headquarters of the Gaian European Republic, a thoroughly unpleasant bunch of oligarchs. A superficially theocratic republic where dissidents are routinely murdered for parts of their brains which form the processing cores for the Gaians war machines. Where people’s remains are cultured and rendered to form ‘Go-Quarn’, a Tofu like substance given to citizens as part of a ‘healthy vegetarian diet’. They were great fun to write. Even more fun to destroy.
This is the great thing about writing science fiction on the grand scale. You can have a great deal of fun simply blowing things (Places, Cities, even whole planets) up. Although in the imaginary future of the ‘Stars’ trilogy, the Gaians see democracy as a primary threat, and spend a great deal of time trying to wipe out said dangerous creed. So it could be argued that the Gaians got what was coming to them.